member of
- Materials Research Society Member 1998 -
- American Institute of Chemical Engineers (AIChE) Member
- Society of Thermal Medicine Member
- Contact Info
Torres-Lugo, Madeline
Positions
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- Publications
- Research
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- Background
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Affiliation
Publications
selected publications
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academic article
- Laparoscopic Induction Heater for Biomedical Applications. IEEE Transactions on Biomedical Engineering. 2018
- HSP70 Inhibition Synergistically Enhances the Effects of Magnetic Fluid Hyperthermia in Ovarian Cancer. Molecular Cancer Therapy. 15:996-976. 2017
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Optimization of synthesis and peptization steps to obtain iron oxide nanoparticles with high energy dissipation rates.
Journal of Magnetism and Magnetic Materials.
394:361-371.
2015
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- Magnetic Fluid hyperthermia Enhances Bortezomib Cytotoxicity in Sensitive and Resistant Cancer Cell Lines . International Journal of Nanomedicine. 9:145-153. 2014
- Nanotechnology Center in Mayaguez: An International Venue on Cutting-Edge Technologies. Dimension - College of Engineers and Surveyors of Puerto Rico. 4:9-17. 2014
- Use of Cross-Linked Poly(ethylene glycol)-Based Hydrogels for Protein Crystallization . Crystal Growth and Design . 14:3239-3248. 2014
- Effect of Surface Charge on the Colloidal Stability and In Vitro Uptake of Carboxymethyl Dextran Coated Iron Oxide Nanoparticles.. Journal of Nanoparticle Research. 15. 2013
- Effect of Surface Charge on the Colloidal Stability and In Vitro Uptake of Carboxymethyl Dextran-Coated Iron Oxide Nanoparticles . Journal of Nanoparticle Research. 15:1874-1888. 2013
- Hyperthermic Potentiation of Cisplatin by Magnetic Nanoparticle Heaters is Correlated with an Increase in Cell Membrane Fluidity. International Journal of Nanomedicine. 8:1003-1013. 2013
- Lysosomal Membrane Permeabilization by Targeted Magnetic Nanoparticles in Alternating Magnetic Fields. ACS Nano. 7:5091-5101. 2013
- Src Activation by B-Adrenoreceptors is a Key Switch for Tumour Metastasis. Nature Communications. 4. 2013
- Synthesis, Stability, Cellular Upatake, and Blood Circulation Time of Carboxymethyl Inulin Coated Magnetic Nanoparticles. Journal of Materials Chemistry B. 1:2807-2817. 2013
- Thermal Potentiation of Chemotherapy by Magnetic Nanoparticles . Nanomedicine . 8:1689-1707. 2013
- Particle Encapsulation in Cross-linked Hydrogel Networks: Particle Distribution Optimization. Journal of Materials Science and Engineering B. 10:539-550. 2012
- Particle Encapsulation in Crosslinked Hydrogel Networks: Distribution and Optimization . Journal of Materials Science and Engineering B. 2:539-550. 2012
- Using a Reduced Dimensionality Model to Compute the Thermodynamic Properties of Finite Polypeptide Aggregates. Journal of Biological Physics. 38:383-395. 2012
- EGFR-Targeted Magnetic Nanoparticle Heaters Kill Cancer Cells without a Perceptible Temperature Rise. ACS Nano. 5:7124-7129. 2011
- Enhanced Reduction in Cell Viability by Hyperthermia Induced by Magnetic Nanoparticles.. International Journal of Nanomedicine. 6:373-380. 2011
- Hyperthermia Induced by Magnetic Nanoparticles Improves the Effectiveness of the Anticancer Drug cis-Diamminedichloroplatinum. Journal of Nanoscience and Nanotechnology. 11:4153-4157. 2011
- Preparation of EGF conjugated magnetic nanoparticles and their internalization into EGFR overexpressing cancer cells . Journal of Magnetism and Magnetic Materials. 322:2244-2250. 2010
- Preparation of Epidermal Growth Factor (EGF) Conjugated Iron Oxide Nanoparticles and their Internalization Into Colon Cancer Cells. Journal of Magnetism and Magnetic Materials. 322:2244-2250. 2010
- The Effect of Grafting Method on the Colloidal Stability and In Vitro Cytotoxicity of Caboxymethyl Dextran Coated Magnetic Nanoparticles. Journal of Materials Chemistry. 20:8539-8547. 2010
- Titanium(IV) Complexes : Cytotoxicity and Cellular Uptake of Titanium(IV) Complexes on Caco-2 Cell Line. Toxicology in Vitro. 24:178-183. 2010
- Weed management during and after rhizome perennial peanut establishment. Journal of Agriculture of the University of Puerto Rico. 94:111-120. 2010
- Poly (Ethylene Glycol)-Based Crosslinked Networks with Potential Multidrug Resistance 1 (MDR1) Protein Inhibition Effects . Journal of Bioactive and Compatible Polymers. 24:444-456. 2009
- Poly(Ethylene Glycol)-based Crosslinked Networks with Potential Multidrug Resistance 1 (MDR1) Protein Inhibition . Journal of Bioactive and Compatible Polymers. 24:444-456. 2009
- Synthesis and Characterization of Carboxymethyl Dextran-Coated Mn/Zn Ferrite for Biomedical Applications. Journal of Magnetism and Magnetic Materials. 321:3061-3066. 2009
- Immobilization of HbI from Lucina Pectinata in Hydrophilic Polymer Networks for the Development of a Hydrogen Sulfide Biosensor. Journal of Applied Polymer Science. 107:881-890. 2008
- Multifunctional Magnetic Nanoparticles Coated with Fluorescent Thermo-Responsive Polymeric Shells. Journal of Materials Chemistry. 18:855-858. 2008
- FTIR Spectroscopic Analysis of Protein/Carrier Interactions in Novel Protein Delivery Systems . STP Pharma . 12:345-350. 2002
- Physicochemical Behavior and Cytotoxic Effects of P(MAA-g-EG) Nanospheres for the Oral Delivery of Proteins . Journal of Controlled Release. 80:197-205. 2002
- pH-Sensitive Hydrogels as Gastrointestinal Tract Absorption Enhancers: Transport Mechanisms of Salmon Calcitonin and other Model Molecules using the Caco-2 Cell Model . Biotechnology Progress . 18:612-618. 2002
- FTIR Spectroscopic Analysis of Protein/Carrier Interactions in Novel Protein Delivery Systems
- Preparation and Characterization of Poly(Methacrylic Acid-grafted-Poly(Ethylene Glycol)) Nanospheres
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conference poster
- Development and Evaluation of a Laparoscopic Induction Heater for Adjuvant Treatment of Peritoneal Cancers. 53rd ACS Junior Technical Meeting (JTM) and 38th Puerto Rico Interdisciplinary Scientific Meeting (PRISM). 2019
- Synthesis and Dynamics of Biocompatible Nanomotors for Biomedical Applications. 53rd ACS Junior Technical Meeting (JTM) and 38th Puerto Rico Interdisciplinary Scientific Meeting (PRISM). 2019
- The Mayagüez Nanotechnology Center: 10 Years of Transformative Impact on Interdisciplinary Research - THe Highlights. 2018 NSF Nanoscale Science and Engineering Grantees Conference, Arlington, VA. 2018
- Optimized High-Energy Dissipating Nanoparticles for Magnetic Hyperthermia in Ovarian Cancer. 2015 Biomedical Engineering Society. 2015
- Tumor-targeted Magnetic Nanoparticles for Thermo-Controlled Drug Delivery. 2nd Puerto Rico Cancer Research Meeting. 2015
- Multi-cellular In Vitro Models for Characterization of Tumor Targeting Efficacy of Nanoparticle Systems. Emerging Researchers National Conference (ERN), Washington, DC . 2015
- Modification of the Co-Precipitation Method to Synthesize Iron Oxide Nanoparticles with Higher Specific Absorption Rates. Emerging Researchers National Conference (ERN), Washington, DC . 2015
- Alginate microbeads for the delivery of composite protein microcrystals . ACS Junior Technical Meeting. 2013
- In vivo assessment of protein microcrystals for antigen delivery . ACS Junior Technical Meeting. 2013
- Magnetic fluid hyperthermia (MFH) produces enhanced potentiation of BZ in BZ sensitive and BZ resistant cancer cells lines . Society for Thermal Medicine . 2013
- Assessment of the Stability and Biological Activity of Heme-Proteins Encapsulated In Hydrogel Membranes . 2008 American Institute of Chemical Engineers (AIChE) Annual Meeting. 2008
- Encapsulation of Protein Crystals in Hydrophilic polymers . Sigma XI Poster Day. 2008
- Lysozyme Crystallization with Neutral Hydrogels Providing Conditions for Counter Diffusion . Sigma XI Poster Day. 2008
- Stability of Lysozyme Crystals in Organic Solvents and Monomers . 2007 AIChE Annual Meeting. 2007
- Assessment of the Biological Stability of Hemoglobin I from Lucina Pectinata and Myoglobin from Horse Skeletal Muscle in Ionic Hydrophilic Polymer Networks . 2006 AIChE Annual Meeting. 2006
- Examination of the Effects of Poly(Ethylene Glycol) (Peg) Rich Matrices on the Transport of Multi Drug Resistance (MDR) and Multi Drug Resistance Associated Protein (MRP) Substrates Utilizing the Caco-2 Cell Model . 2006 AIChE Annual Meeting. 2006
- Magnetic Nanoparticles with Thermoresponsive Polymeric Shells for Biomedical Applications . 2006 AIChE Annual Meeting. 2006
- Studies of Ferrite Based Magnetic Nanoparticle Transport Mechanisms and Magnetocytolysis Effects on a Model Cell Cultures . 2006 AIChE Annual Meeting. 2006
- Studies of Ferrite Based Magnetic Nanoparticle Transport Mechanisms and Magnetocytolysis Effects on a Model Cell Cultures . 2006 AIChE Annual Meeting. 2006
- Surface Modification of Magnetite (Fe3o4) Nanoparticles for Cancer Treatment . 2006 AIChE Annual Meeting. 2006
- Effects of Template-monomer Complex Formation on the Synthesis of Molecularly Imprinted Polymers in Aqueous Medium . 2005 AIChE Annual Meeting. 2005
- Energy Dissipation and Nanoparticle Transport in Magnetic Fluid Hyperthermia Treatment of a Spherical Cancer Tumor . 2005 AIChE Annual Meeting. 2005
- Molecular Studies of Proteins Encapsulated in Hydrogels . AiChE . 2005
- Synthesis and Characterization of pH-Sensitive Poly(Ethylene Glycol) . 2005 AIChE Annual Meeting. 2005
- Synthesis and functionalization of magnetite (Fe3O4) nanoparticles for cancer treatment . 2005 AIChE Annual Meeting. 2005
- Characterization of Immobilization of Myoglobin from Horse Skeletal Muscle (Mb) and Hemoglobin I (Hb I) form Lucina Pectinata in Hydrophillic Polymer Networks for H2S biosensor Application. Current Trends in Biotechnology and Pharmaceutical Engeneering Symposium . 2004
- Examination of the Cytotoxic Effects and Transport of Magnetite Nanoparticles utilizing the Caco-2 Cell Model . First Transdiciplinary Research Conference. 2004
- Synthesis and Characterization of Poly(ethylene glycol)-Rich Hydrogel Networks for Controlled Drug Delivery Applications . Sigma XI Poster Day. 2004
- Synthesis and Characterization of Poly(ethylene glycol)-Rich Hydrogel Networks for Controlled Drug Delivery Applications . Sigma XI Poster Day. 2004
presentations
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invited talk
- A Comprehensive Approach to Cancer Treatment Using Magnetic Nanoparticles: From Basic Engineering to In Vivo Studies , Speaker, Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX 2012
- Using Crosslinked Hydrogels for the Control of Macromolecular Crystallization , Speaker, Laboratorio Espanol de Cristalizacion 2010
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presentation
- Cell Death during Magnetic Fluid Hyperthermia at a Constant Thermal Dose: Does it Matter How the Magnetic Field is Applied? , Speaker, 2013 Annual Meeting of the Society for Thermal Medicine 2013
- In Vivo Assessment of Temporal and Spatial Behavior of Carboxyl Methyl Dextran Iron Oxide Nanoparticles in Breast and Ovarian Cancer Models , Speaker, 2013 AIChE Annual Meeting 2013
- In Vivo Biodistribution of Carboxyl Methyl Dextran Iron Oxide Nanoparticles for Localized Magnetic Fluid Hyperthermia in Ovarian Cancer Models , Speaker, Emerging Researchers National (ERN) Conference, Atlanta, GA 2013
- Novel Composite Protein Microcrystals for the Sustained Oral Delivery of Antigens , Speaker, 46th ACS Junior Technical Meeting 2013
- Proteotoxic Stress Induced By Magnetic Fluid Hyperthermia (MFH) Enhances Bortezomib Cytotoxicity , Speaker, 2013 AIChE Annual Meeting 2013
- Proteotoxic Stress Induced By Magnetic Fluid Hyperthermia (MFH) Enhances Bortezomib Cytotoxicity , Speaker, 2013 AIChE Annual Meeting 2013
- Proteotoxic Stress Induced By Magnetic Fluid Hyperthermia (MFH) Enhances Bortezomib Cytotoxicity , Speaker, 2013 AIChE Annual Meeting 2013
- Synergistic potentiation of cisplatin with magnetic fluid hyperthermia (MFH) in Cacoâ2 cells is correlated with an increase in cell membrane fluidity , Speaker, Emerging Researchers National (ERN) Conference, Atlanta, GA 2013
- Synergistic potentiation of cisplatin with magnetic fluid hyperthermia (MFH) in Cacoâ2 cells is correlated with an increase in cell membrane fluidity , Speaker, Emerging Researchers National (ERN) Conference, Atlanta, GA 2013
- Understanding the Thermopotentiation of Anticancer Drugs by Magnetic Fluid Hyperthermia , Speaker, Society for Thermal Medicine 2013
- Protein Denaturation During Magnetic Fluid Hyperthermia at a Constant Thermal Dose: Does it Matter How the Magnetic Field is Applied?, Speaker, 9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2012
- Synergistic Potentiation of Cisplatin with Magnetic Fluid Hyperthermia in Caco-2 Cells , Speaker, Society for Thermal Medicine 2012
- Diffusion Controlled Macromolecular Crystallization using Crosslinked Hydrogels , Speaker, XXV Interamerican Congress of Chemical Engineering, Santiago, Chile 2011
- Synergistic Potentiation of Anticancer Drugs with Magnetic Fluid Hyperthermia: In Vitro Studies , Speaker, XXV Interamerican Congress of Chemical Engineering, Santiago, Chile 2011
- Effects of Nanoparticle Surface Charge on Cellular Mechanisms of Internalization , Speaker, 2010 AIChE Annual Meeting 2010
- Examination of the Enhanced Potentiation of Combined Cisplatin Treatment with Magnetic Fluid Hyperthermia , Speaker, 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2010
- Examination of the Enhanced Potentiation of Combined Cisplatin Treatment with Magnetic Fluid Hyperthermia , Speaker, 8th International Conference on the Scientific and Clinical Applications of Magnetic Carriers 2010
- Effects of Nanoparticle Properties On Cellullar Uptake and Magnetic Fluid Hyperthermia , Speaker, 2009 AIChE Annual Meeting 2009
- Synthesis, Colloidal Stability, and Magnetic Properties of Nanoparticles for Magnetic Fluid Hyperthermia , Speaker, 2009 AIChE Annual Meeting 2009
- Synthesis, Colloidal Stability, and Magnetic Properties of Nanoparticles for Magnetic Fluid Hyperthermia , Speaker, 2009 AIChE Annual Meeting 2009
- Poly(Ethylene Glycol) Hydrogels as Possible Multidrug Resistance Associated Protein (MRP) Inhibitors , Speaker, EMBS Lyon France 2007
- Poly(Ethylene Glycol) Hydrogels as Possible Multidrug Resistance Associated Protein (MRP) Inhibitors , Speaker, EMBS Lyon France 2007
- The Effect of Pre-Polymeric Solution and Subsequent Encapsulation in Hydrogel Membranes on the Stability and Biological Activity of Horse Myoglobins , Speaker, EMBS Lyon France 2007
- Insight the Rational Design of Molecularly Imprinted Polymer for the Development of Biomimetic Receptors , Speaker, 2006 AIChE Annual Meeting 2006
- Insight the Rational Design of Molecularly Imprinted Polymer for the Development of Biomimetic Receptors , Speaker, 2006 AIChE Annual Meeting 2006
- Cytotoxicity and cellular transport of magnetite nanoparticles utilizing the Caco-2 cell model , Speaker, 2005 AIChE Annual Meeting 2005
- Novel Method for the Release of Hydrocortisone from Molecularly Imprinted Polymer Thin Films with Supercritical Fluids, Speaker, 2005 AIChE Annual Meeting 2005
- Synthesis and functionalization of magnetite (Fe3O4) nanoparticles for cancer treatment , Speaker, 2005 AIChE Annual Meeting 2005
- Examination of the Cytotoxic Effects of PEG-Rich Matrices utilizing the Caco-2 Cell Model , Speaker, Princeton University 2004
- Intelligent Polymers for Biomedical Applications, Speaker, Biologia UPRM 2004
- Nanotechnology Center and its Application to Biomedical Innovation , Speaker, Forum for Innovation 2004
- Biomedical and Biochemical Engineering Research in Chemical Engineering , Speaker, Biomedical Engineering Colloquium 2003
- Novel Approach for the Manipulation of Water Uptake, Morphology and Permeability in pH-Sensitive Hydrogels , Speaker, 2003 AIChE Annual Meeting 2003
- Physicochemical Behavior and Cellular Interactions of Novel Oral Calcitonin Delivery Systems , Speaker, 2002 AIChE Annual Meeting 2002
- Transport Mechanisms of Calcitonin thorugh Caco-2 Cell Monolayers , Speaker, 2001 AIChE Annual Meeting 2001
- Analisis de Distribucion de Diferentes Componentes dentro de Peliculas Polimericas Usando Imagenes Quimicas de Infrarrojo Cercano, Collaborator, XXIX Congreso Latinoamericano de Quimica
- Molecular Studies of Proteins Encapsulated in Hydrogels, Speaker, 2005 AIChE Annual Meeting
Research
other research activities
- CREST Phase II: Nanotechnology Center for Biomedical, Environmental and Sustainability Applications Co-PI 2014 - 2019
- In vivo Assessment of Localized Magnetic Fluid Hyperthermia PI 2013 - 2016
- Nanotechnology from Basic Science to Emerging Applications: Institute for Functional Nanomaterials (IFN) Co-PI 2010 - 2016
- Examination of Protein Crystal Confinement in Polymer Systems PI 2009 - 2015
- RISE-2-BEST program at UPRM: Enhancing Biomedical Sciences and Biomedical Engineering in Science and Technology Collaborator 2010 - 2014
- Multifunctional Nanoparticles for Magnetically Actuated siRNA Delivery Co-PI 2008 - 2012
- Magnetically and Thermally Active Nanoparticles for Cancer Treatment Co-PI 2006 - 2011
- Molecular Studies of Proteins Encapsulated in Soft Materials PI 2004 - 2008
- Examination of the Physicochemical Interactions of Poly(Ethylene Glycol)-Rich Matrices with the MRP and MDR Efflux Pumps PI 2003 - 2007
- Studies of Magnetite Nanoparticle Cytotoxicity and Transport in Caco-2 Cells and Magnetic Field Induced Hyperthermia Co-PI 2004 - 2005
- Confocal Laser Scanning Microscope Facility PI 2002 - 2004
Service
reviewer of
- Biomacromolecules (Journal)
- Biomaterials (Journal)
- European Journal of Pharmaceutics and Biopharmaceutics (Journal)
- Journal of Applied Polymer Science (Journal)
- Journal of Controlled Release (Journal)
professional service activities
- Center for Biomedical Engineering and Nanomedicine Director 2013 -
- Departmental Personnel Committee - Department of Chemical Engineering Member 2010 -
- Departmental Graduate Affairs Committee - Department of Chemical Engineering Member 2003 -
- Academia de Investigacion Para la Facultad y Postdoctorales Mentor
- National Science Foundation (NSF) Proposal Reviewer (Panels: CTS, NIDDK, MRI)
- Departmental Personnel Committee - Department of Chemical Engineering Member 2006 - 2008
- Departmental Academic Affairs Committee - Department of Chemical Engineering Member 2002 - 2006
Background
education and training
- Ph.D. in Chemical Engineering, Purdue University 2001
- M.S. in Chemical Engineering, Purdue University 1999
- B.S. in Chemical Engineering 1997
awards and honors
- Chemical Engineering Innovative Women in Education, 2010
- Distinguished Professor of Chemical Engineering, conferred by Department of Chemical Engineering ., 2005
- Magoon Award for Excellence in Teaching , conferred by Purdue University, 2000
- GEM PhD Fellowship, 1999
- Fearnot Award Winner , conferred by Purdue University, 1999
- Fearnot Award Winner , conferred by Purdue University, 1999
- GEM Master Fellowship, 1998
- Gold Medal Award Winner , conferred by Material Research Society Meeting , 1998
Contact
full name
- Madeline Torres Lugo