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Alcala, Manel

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Publications

selected publications

• academic article

  • Near-Infrared Spectroscopy in Laboratory and Process Analysis .  Encyclopedia of Analytical Chemistry.  2012
  • Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding/Part II: Quantification of Enhanced Flow Properties of Surface Modified Active Pharmaceutical Ingredients.  Journal of Pharmaceutical Innovation.  5:1-13. 2010
  • Real-time monitoring of drug concentration in a continuous powder mixing process using NIR spectroscopy.  Chem. Eng. Sci. .  65:5728-5733. 2010
  • Deconvolution of Chemical and Physical Information From Intact Tablets NIR Spectra. Two- and Three- Way Multivariate Calibration Strategies For Drug Quantitation.  Journal of Pharmaceutical Innovation.  98:2747-2758. 2009
  • Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding/Part I: Development of the Methodology.  Journal of Pharmaceutical Innovation.  4:187-197. 2009
  • Analysis of low content drug tablets by transmission near infrared spectroscopy: Selection of calibration ranges according to multivariate detection and quantitation limits of PLS models.  Journal of Pharmaceutical Sciences.  97:5318-5327. 2008
  • Design and In-Line Raman Spectroscopic Monitoring of a Protein Batch Crystallization Process.  Journal of Pharmaceutical Innovation.  3:271-279. 2008
  • The Time for Process Understanding.  Pharmaceutical Technology Europe.  20:26-31. 2008

• chapter

  • A Procedure for Developing Quantitative Near Infrared (NIR) Methods for Pharmaceutical Products.  Process Simulation and Data Modeling in Solid Oral Drug Development and Manufacture. Ed. Ierapetritou, Marianthi.  New York: Springer. 133-158. 2015

• review

  • Continuous Manufacturing, Near Infrared Spectroscopy and Process Knowledge. .  American Pharmaceutical Review. 59-63. 2015

presentations

• presentation

  • Additional Studies in the Validation of a NIR Method for Drug Concentration in Tablets, Collaborator, 36th ACS Senior Technical Meeting
  • Analysis of low content drug tablets by transmission near infrared spectroscopy. Selection of calibration ranges according to multivariate detection and quantitation limits of PLS Models, Collaborator, 43rd ACS Junior Technical Meeting
  • Bulk Density and Concentration Analysis for Different APAP Formulations Using NIR Spectroscopy, Collaborator, 43rd ACS Junior Technical Meeting
  • Deconvolution of chemical and physical information of NIR spectra. Two- and three-way calibration strategies for drug quantitation of intact tablets, Collaborator, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
  • Determination of Tablet Relaxation Through Real Time NIR Spectroscopy of Moving Tablets, Collaborator, 31st ACS Senior Technical Meeting
  • Development of Calibration Model for Its Implementation in a Continuous Manufacturing Process in a Pharmaceutical Industry, Collaborator, 36th ACS Senior Technical Meeting
  • Evaluation of Gel Strip Homogeneity Using NIR Spectroscopy, Collaborator, 43rd ACS Junior Technical Meeting
  • Evaluation of Strain and Shear Effects in Pharmaceutical Blends using Near Infrared Spectroscopy, Collaborator, 43rd ACS Junior Technical Meeting
  • Lets Get Physical - The Real Need For NIR Spectroscopy In Monitoring And Controlling Pharmaceutical Processes, Collaborator, 31st ACS Senior Technical Meeting
  • Near-infrared Spectroscopy as a Reliable method for the detection of physical and chemical property changes, Collaborator, 43rd ACS Junior Technical Meeting
  • Real Time Determination of Tablet Compaction Pressure in Moving Tablets, Collaborator, 6th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Contact

full name

• M. Alcala