- Contact Info
-
(787) 832-4040
X-2538 (Office)
X-2348 (Lab)
Rios-Steiner, Jorge L.
Positions
- Associate Professor, Department of Chemistry , College of Arts and Sciences
- Affiliation
- Publications
- Research
- Service
- Background
- Contact
- View All
Affiliation
Publications
selected publications
-
academic article
- Design and In-Line Raman Spectroscopic Monitoring of a Protein Batch Crystallization Process. Journal of Pharmaceutical Innovation. 3:271-279. 2008
- Active- and Exo-site inhibition of Human Factor Xa: Structure of des-Gla Factor Xa Inhibited by NAP5, a Potent Nematode Anticoagulant Protein from Ancylostoma caninum. J. Mol. Biol.. 366:602-610. 2007
- Intermolecular interactions and characterization of the novel factor Xa exosite involved in macromolecular recognition and inhibition: Crystal Structure of human Gla-Domainles factor Xa complexed with the anticoagulant protein NAPc2 form the hematophagous nematode Ancylostoma caninum. J. Mol. Biol.. 366:602-610. 2007
- Crystal Structure of 2-keto-3-deoxy-6-phosphogluconate (KDPG) Aldolase from Pseudomonas putida. Acta Cryst.. 1454-1458. 2003
- Structural Basis of m7GpppG binding to the nuclear Cap-binding protein complex. Nat. Struct. Biol. 9:912-917. 2002
- The X-ray Crystallographic Structure of Escherichia coli Branching Enzyme. J. Biol. Chemistry. 277:42164-42170. 2002
- Structure and Binding Determinants of the Recombinat Kringle-2 Domain of Human Plasminogen to an Internal Peptide from a Group A Streptococcal Surface Protein. J. Mol. Biol.. 308:705-719. 2001
- Phytotoxins from the Septoria spp. plant pathogenic fungus on leafy spurge. Biosci. Biotech. Bioch.. 62:638-642. 1998
- Structure of Thrombin Inhibited by Aeruginosin 298-A from a Blue-Green Alga. J. Am Chem. Soc.. 120:597-598. 1998
- New terpenoid metabolites from the skin extracts, an egg mass, and dietary sponges of the Northeastern Pacific dorid nudibranch Cadlina luteomarginata. Can. J. Chem.. 75:773-789. 1997
- Structure of the Spiroketal- Macrolide Ossamycin. J. Antibiot.. 49:162-167. 1996
- Elucidation of the Structure of Ossamycin and Stereochemical Comparisons with other Spiro ketal Macrolides. Abstr. Pap. Am. Chem. S. . 210. 1995
- Structure of the New Spiroketal- Macrolide A82548A. J. Antibiot.. 48:990-996. 1995
- Halomon Analogs - Additional Halogentated Monoterpenes from Portieria hornemannii with a Novel In-Vitro Antitumor Response Profile. Abstr. Pap. Am. Chem. S. . 208. 1994
- Isolation and Structure - Activity Features of Halomon - Related Antitumor Monoterpenes from the Red Alga Portieria hornemannii. J. Med. Chem.. 37:4407-4411. 1994
- Solid-State and Solution Conformations ofthe Potent HIV Inhibitor, 4'-Azidothymidine. J. Med. Chem.. 37:431-438. 1994
- Structure and biosynthesis of borophycin, a new boeseken complex of boric acid from a marine strain of the bluegreen alga Nostoc linckia. Journal of Organometallic Chemistry. 59:3467-3471. 1994
- The Structures of Amphidinolide-B Isomers-Strongly Cytotoxic Macrolides produced by a Free-Swimming Dinoflagellate, Amphidinium sp.. J. Am Chem. Soc.. 116:2657-2658. 1994
- X-Ray Crystallographic Structure and Absolute - Configuration of NPS R-568, A Clinical Candidate for the Treatment of Hyperparathyroidism. Abstr. Pap. Am. Chem. S. . 208. 1994
- 3 Pregnane-10,2-Carbolactones From A Sponge, Strongylophora sp.. Tetrahedron. 49:1557-1562. 1993
- Balanol- A Novel and Potent Inhibitor of Protein-Kinase-C from the Fungus Verticillium balanoides. J. Am Chem. Soc.. 115:6452-6453. 1993
- HIV Inhibitory Natural-Products. 11. Structure, Absolute Stereochemistry and Synthesis of Conocurvone, a Potent, Novel HIV-Inhibitory Naphthoquinone Trimer from a Conospermum sp.. J. Am Chem. Soc.. 115:6673-6679. 1993
- New Polychlorinated Amino-Acid Derivatives from the Marine Sponge Dysidea herbacea. Journal of Organometallic Chemistry. 58:6336-6343. 1993
- Nostoclide I and II, Extracellular Metabolites from a Symbiotic Cyanobacterium, Nostoc sp, from the Lichen Peltigera canina. Tetrahedron. 34:761-764. 1993
- The Absolute Configuration ofBacillariolide-I and Bacillariolide-II, a New Type of Cyclopentane Icosanoids from A Marine Diatom. J. Chem. Soc. Chem. Comm. . 4:379-381. 1993
- Viridoxin-A and Viridoxin-B-Novel Toxins from the Fungus Metarhizium flavoviride. Journal of Organometallic Chemistry. 58:1062-1067. 1993
- Smenochromenes, Unusual Macrocyclic Sesquiterpene Hydroquinone Derivatives from a Seychelles Sponge of the Genus Smenospongia. Journal of Organometallic Chemistry. 56:6271-6274. 1991
- Structure and Absolute Configuration ofPyrophen, a Novel Pyrone Derivative of L-Phenylalanine from Aspergillus niger. Int. J. Pept. Prot. Res. . 36:292-296. 1990
- Structure of 4,7,8-Trirnethoxyfuro[2,3-b]Quinoline. Acta Cryst.. 44:1323-1324. 1989
- 3-(2-Methyl-l,3-Dioxolan-2-yl)-2-(Methy1diphenylsilyl)Propionate. Acta Cryst.. 44:1323-1324. 1988
- Crystal and Molecular-Structure of Destruxin-B. Int. J. Pept. Prot. Res. . 31:212-219. 1988
-
thesis
presentations
-
presentation
- A Partial Least Squares Calibration Method to Determine Lysozyme Concentration Using Raman Spectroscopy, Collaborator, 41st ACS Junior Technical Meeting
- Cryptand 2B.2B.2: Structures of a Ba+2 Complex and a Hydrated HCI Adduct, Speaker, American Crystallographic Association, Stanford University
- In line Monitoring Protein Crystallization using Raman and Infrared Spectroscopy, Collaborator, Excipientfest Puerto Rico
- In-Line Monitoring Protein Crystallization, Collaborator, Latin American and Caribbean Biotechnology Congress, Poster Presentation
- Intensity Comparisons of the New Osmic Confocal Max-Flux Optics TM with Total Reflection Mirrors, Speaker, American Crystallographic Association, Arlington VA
- Pyrophen, a Novel Pyrone Derivative of L-Phenylalanine from Asperillus Niger, Speaker, American Crystallographic Association, Philadelphia PA
- Spectral Changes Observed with In-Line Raman Spectroscopic Monitoring of Protein Crystallization, Collaborator, 31st ACS Senior Technical Meeting
- Temperature Effects on Raman Spectra of Proteins in Aqueous Solutions, Collaborator, Excipientfest Puerto Rico
- The Crystal Structure of Destruxin B, Speaker, XIV International Congress of Crystallography, Perth, Australia
- The Crystal Structure of a-Thrombin with a New Type ofInhibitor: Aeruginosin-298A, Speaker, XVII International Congress of Crystallography
- Using Raman Spectroscopy to Design a Protein Crystallization Process, Collaborator, 5th Annual IFPAC/PAT/QbD Summit
Research
other research activities
- Polymer Confinement of Protein Crystals:an InnovativeApproach to Controlled Drug Release Collaborator
- Structural Studies of Chemical Molecules of Organic, Inorganic and Solid Material Nature using single crystal Xi-ray Crystallography PI 2006 - 2008
- Molecular Studies of Proteins Encapsulated in Soft Materials Collaborator 2004 - 2008
- Center for Research in Protein Structure, Function and Dynamics Co-PI 2001 - 2007
- In Line Monitoring and Control of Protein Crystallization Collaborator 2004 - 2006
- Protein Structure, Function and Dynamics Co-PI 2004 - 2005
- Protein: Structure, Function and Dynamics Collaborator 2000 - 2005
- Structure of Catalytic Domains of Blood Proteins Collaborator 1996 - 1999
- New Anticancer Drugs from Collected and Cultured Marine Organisms Collaborator 1991 - 1994
Service
professional service activities
- Argonne National Laboratory, Argonne, IL Senior Research Associate 2000 - 2002
- Baker Lab. Director of X-ray Facility 1992 - 1994
Background
education and training
- Ph.D. in Chemistry, University of Puerto Rico, Rio Piedras. 1991
- B.Sc. in Chemistry, University of Puerto Rico, Rio Piedras. 1984
Contact
full name
- Jorge L Rios Steiner
mailing address
-
P.O. Box 9019
Mayaguez, PR 00681-9019
United States of America